Neurohormonal Activation and Left Atrium Remodeling in Mitral Stenosis

Neurohormonal Activation and Left Atrium Remodeling in Mitral Stenosis

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Mitral stenosis is closely related with the hemodynamic consequences of obstructed mitral leaflet.Definitive therapy in mitral stenosis is mechanical intervention.Late presentation of mitral stenosis patients to medical facilities due to limited health facilities and Indonesians demographic, flexcon reverse osmosis water storage tank often make patients condition deteriorates, in which intervention need to be delayed or even no here longer suitable.Stretched left atrium and reduced cardiac output stimulate several neurohormonal activation; renin-angiotensin-aldosterone and symphatetic nervous system.Left atrial remodeling further worsen hemodynamic ststus.

Renin-angiotensin-aldosterone and sympathetic blockage could improve mitral stenosis patients condition with close observation to hypotension status.